News and Events > GlobeImmune and MycoLogics Enter Tarmogen™ Technology Collaboration for Antifungal Therapeutics

GlobeImmune and MycoLogics Enter Tarmogen™ Technology Collaboration for Antifungal Therapeutics

January 17, 2005

Boulder, CO - GlobeImmune and Mycologics announce today that they have signed a non-exclusive research license and option agreement under which Mycologics will pursue select antifungal products under the GlobeImmune TarmogenT Technology. The license agreement enables MycoLogics to enter into proof of concept pre-clinical testing of human and animal candidate vaccines targeting the fungal diseases aspergillosis, coccidioidmycosis, cryptococcosis and the disease leishmaniasis. Both fungal and parasite research and development projects are fully supported by NIH SBIR and STTR awards.

Tarmogens are whole, heat-killed recombinant Saccharomyces cerevisiae genetically modified to express one or more protein antigens that stimulate the immune system against diseased cells. Tarmogens are avidly taken up by the cells that activate the immune system called antigen presenting cells, to stimulate a T cell response against the desired target(s). GlobeImmune's patented Tarmogen platform has a number of advantages over current approaches including that Tarmogens generate potent T cell immune responses, are not neutralized by the immune system, can be rapidly engineered and are simple and inexpensive to manufacture.

"This represents the first strategic license of the Tarmogen Technology for GlobeImmune," said Dr. Timothy C. Rodell, CEO of GlobeImmune, "we are very pleased to have MycoLogics as a partner in the antifungal field."

"Tarmogens represent a potent new technology with broad potential," said Dr. Claude P. Selitrennikoff, Ph.D., President and CEO of MycoLogics, "this agreement allows us to go forward with the development of prophylactic and therapeutic vaccines for treatment of a number of fungal and parasitic diseases."

ABOUT MYCOLOGICS, INC.

MycoLogics, Inc., is an innovative biotechnology company specializing in the development of novel antifungal drugs and therapeutic and prophylactic vaccines against human fungal and parasitic pathogens, the discovery and isolation of novel antifungal compounds for therapeutic use, and the development of novel high throughput assays that target components of fungal cell walls. MycoLogics, Inc. is headquartered in Aurora, CO at the Fitzsimons Colorado Bioscience Park. For more information please visit www.mycologics.com .

ABOUT GLOBEIMMUNE, INC .

GlobeImmune, Inc., is an emerging biopharmaceutical company pioneering the discovery, development and manufacturing of potent, targeted molecular immunotherapies for the treatment of cancer and infectious diseases. The Company's first products for the treatment of cancers of the lung and gastrointestinal tract are currently in Phase 1 clinical trials. For additional information, please visit the company's website at www.globeimmune.com .

CONTACT INFORMATION:

Timothy C. Rodell, M.D., FCCP
Chief Executive Officer
GlobeImmune, Inc.
Tel: (303) 859-4070
Fax: (303) 859-4065
Email: info@globeimmune.com

Claude P. Selitrennikoff, Ph.D
President and CEO
MycoLogics, Inc.
Tel: (303) 724-3426
Fax: (303) 724-0861